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Oral ED medicines might not work or might be dangerous if you also take any of the following: Nitrate medicines. Medicines that you take by mouth are called oral medicines. Your health information should remain between your provider and yourself. This allows the smooth muscles in the penis to relax and fill with blood. These small differences affect the way each medication works, such as how quickly it takes effect and wears off, and the possible side effects. Generic vs. However, all medications come with risks.Viagra is usually taken only when needed, 30 minutes to 1 hour before sexual activity. You may take it up to 4 hours before sexual activity. Stop taking sildenafil and get . Viagra (sildenafil): As the first FDA-approved PDE5 inhibitor for ED, sildenafil is taken Yes, Viagra works to treat ED in most people. It increases blood flow to the penis to help you get or keep an erection. If Viagra doesn’t work for you, talk with your doctor.